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Genotype-Tissue Expression (GTEx) (12) (see URLs) data showed that genotypes for rs72658409 are suggestively associated with expression level of CDKN2B gene (P = 0.04) but not CDKN2B-AS1 (P = 0.1) in normal lung tissue samples (n = 123) (Supplementary Material, Figs S2a and b). rs11610143 resides in a conserved region inferred by both GERP(13) and SiPhy (14), and it influences promoter histone marks in 8 organs including lung carcinoma and enhancer histone marks in 18 organs including fetal lung. Additionally, rs11610143 has a RegulomeDB (15) score of 4 with minimal evidence supporting transcription factor binding site (Supplementary Material, Table S3) Read more↗

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Updated11 months ago
Checked2 weeks ago
Keywordsddv494 supplementary data zip ddv

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